Three different signs.
The “Quiet Zone” sign is somewhat ironic, as it is on the edge of the George Washington University campus and three blocks from the GWU Hospital. It does seem to work, at least when I’m in the area, as I don’t see roving hordes of GW undergrads partying it up on the street, but it of course has zero impact on the ambulance sirens.

The “Open” arrow is outside Nellie’s Sports Bar, the first gay sports bar perhaps anywhere. What is a gay sports bar? Well, it’s a gay bar that has lots of very large flatscreen TVs, all of which are tuned to various flavors of ESPN, and it actually sponsors a number of teams in various gay sports leagues around the city. The “Open” arrow is a found object they re-purposed and fixed up to put outside the bar.

This is the sign for the Backbar, part of the famous 9:30 Club. The 9:30 Club is a major rock-n-roll venue and has been around since 1980. It used to be located much further downtown, at something like 9th and F streets, but maybe 15 years ago moved to the current location which is roughly 9th and V Streets. They host major acts for a “small” venue – Billy Idol, Jimmy Somerville are two I can remember off the top of my head.
